PROHIBITED SUBSTANCES AND MEDICATION RULES
Horses competing on Saudi Cup day (Saturday 29 th February 2020) and in the International Jockeys Challenge races (Friday 28 th Feb 2020) will be subject to testing for “prohibited substances” in accordance with the requirements set out in Article 6 of the International Agreement of the International Federation of Horseracing Authorities (IFHA), and as bound by the Racing Rules of the Jockey Club of Saudi Arabia (JCSA Rules). Horses are tested for the presence of “prohibited substances” through the routine collection of both pre-and post-race blood and urine samples.
A prohibited substance is considered to be any substance that is capable of acting directly or indirectly on any of the mammalian body systems, consistent with the model definition in Article 6 of the IFHA International Agreement. A prohibited substance means a substance (including its metabolites, isomers and artifacts) which falls into any of the categories specified in these rules and/or as listed by JCSA from time to time.
According to Article 119 of the JCSA Rules, the following are prohibited substances:
(1) Substances capable at any time of causing either directly or indirectly an action or effect, or both an action and effect, within one or more of the following mammalian body systems:-
(2) Substances falling within, but not limited to, the following categories:
(3) Metabolites, artifacts and isomers of the Prohibited Substances prescribed by Sub-Rules (1) and (2) of this Rule.
The JCSA gives notice that the following substances are also deemed to be prohibited substances when present above these thresholds:
• Prednisolone – 0.01 microgram free prednisolone per millilitre in urine
• Total carbon dioxide – 36 millimoles per litre in plasma
• Arsenic – 0.3 microgram total arsenic per millilitre in urine
• Total cobalt at a mass concentration of 0.1 micrograms per millilitre in urine or 0.025 microgram total cobalt (free and protein bound) per millilitre in plasma
• Boldenone – 0.015 micrograms free and conjugated boldenone per millilitre in urine from male horses (other than geldings)
• Dimethyl sulphoxide – 15 micrograms per millilitre in urine or 1 microgram per millilitre in plasma
• In male horses other than geldings, 0.045 microgram free and glucuroconjugated 5α-estrane-3β, 17α-diol per millilitre in urine when, at the screening stage, the free and glucuroconjugated 5α-estrane-3β, 17α-diol exceeds the free and glucuroconjugated 5(10)-estrene-3β, 17α-diol in urine
• Hydrocortisone – 1 microgram hydrocortisone per millilitre in urine
• Methoxytyramine – 4 micrograms free and conjugated 3-methoxytyramine per millilitre in urine
• Salicylic acid – 750 micrograms salicylic acid per millilitre in urine or 6.5 micrograms per millilitre in plasma
• Testosterone – 0.02 microgram free and conjugated testosterone per millilitre in urine from geldings, or 100 picograms free testosterone per millilitre in plasma from geldings, fillies and mares (unless in foal), or 0.055 microgram free and conjugated testosterone per millilitre in urine from fillies and mares (unless in foal)
Only levels above the thresholds shall be taken as positive
For the purpose of the Saudi Cup Races, the following classifications also apply:
Substances prohibited at all times:
Substances that have no legitimate justification for use in racehorses at any time under a zero-tolerance policy. They include but are not limited to:
• Substances which have no current approval by any government regulatory authority for veterinary use, or any substance not universally recognised by veterinary regulatory authorities as valid veterinary therapeutic treatment
• Anabolic agents including anabolic steroids
• Peptide hormones, growth hormones, growth factors and related substances
• Oxygen carriers
• Erythropoiesis stimulating agents
• Haematopoietic agents
• Venoms of any species or derivatives thereof
• Hormones and metabolic modulators such as insulins, agents modifying myostatin function and selective estrogen receptor modulators
Substances with a legitimate therapeutic use:
This category includes substances that are “prohibited substances” but which are not included in the list of substances which are prohibited at all times. They are permitted for use on a horse in training but cannot be detected in a race day sample. These substances include anti-inflammatory agents licensed for use in horses, and other medications used in the legitimate management of conditions during training.
Relevant international screening limits (ISL’s) for therapeutic substances in urine and plasma will apply during the screening of samples from horses competing in Saudi Cup Races. (See: https://www.ifhaonline.org/default.asp?section=IABRW&area=1 and https://www.ifhaonline.org/default.asp?section=IABRW&area=6)
The JCSA also accepts the following Asian Screening Limits for controlling Firocoxib, Ketoprofen and Dantrolene in plasma:
* Firocoxib: 2ng/mL in plasma.
* Dantrolene: 0.1 ng/mL of 5-hydroxydantrolene in plasma.
* Ketoprofen: 2 ng/mL in plasma under the condition of a single IV or oral dose.
The JCSA also accepts the IFHA residue limits for the control of Feed Contaminants and Environmental Substances as set out at:
TCO₂ testing and alkalinising agents
The JCSA has stringent procedures for the testing of total carbon dioxide (TCO₂) in blood samples taken pre-race. There are clear restrictions on the pre-race administration of alkalinising agents which are highlighted in the Notices section of the JCSA Rules and set out below.
The following TCO₂ testing procedures will apply for horses competing in the Saudi Cup races:
• Horses will be tested for TCO₂ pre-race.
• Horses will be brought to the testing area 45-50 minutes before race time – blood is taken and where analysis shows that a horse has a level of between 36 mmol/L and 37 mmol/L, a second test is taken 10 minutes later.
• If the second test is equal to or above 37 mmol/L the horse is scratched. A third test is taken 30 minutes later and if the TCO₂ level is below the permitted level, no penalty is imposed on the trainer.
• A horse sent for a third test will also be sent for blood sampling which will be taken in the normal manner to that which is already done on a race day under a secure chain of custody and this sample will be sent for further testing for prohibited substances.
JCSA Rules Notice
1. ALKALINISING AGENTS
1) A person must not administer an alkalinising agent, in any manner, to a horse which is engaged to run in any race.
2) Any person who:
a) administers an alkalinising agent;
b) attempts to administer an alkalinising agent;
c) causes an alkalinising agent to be administered; and/or
d) is a party to the administration of, or an attempt to administer, an alkalinising agent, contrary to Article 119 commits an offence and may be penalised.
3) Where the Stewards are satisfied that a horse has, or is likely to have been, administered any alkalinising agent contrary to Article 119, the Stewards may prevent the horse from starting in any relevant race.
4) Where a horse has been administered any alkalinising agent contrary to Article 119, the horse may be disqualified from any relevant race in which the horse competed.
5) For the purposes of Article 119, ‘alkalinising agent’:
a) means any substance that may elevate the plasma total carbon dioxide (TCO₂) of a horse when administered by any route;
b) includes but is not limited to substances that are bicarbonates, citrates, succinates, acetates, propionates, maleates, lactates and trometamol (THAM, Tris
Buffer or Trometamine) and also include products marketed as urinary alkalinisers and hind gut buffers;
c) does not include substances:
that are alkalinising agents which are contained in commercial feeds and/or balanced commercial electrolyte supplements which when fed and consumed according to the manufacturers’ recommendations for normal daily use have a negligible effect on plasma TCO₂.
Specific requirements regarding bisphosphonates
The following Notice appears in the JCSA Rules:
Any bisphosphonate is not to be administered to a racehorse:
• under the age of three years and six months as determined by its recorded date of birth; and
• on the day of the race or on any of the 30 days before the day of the race in which the horse is declared to run.
The bisphosphonate product administered must be licensed for use in horses in the country in which it is being used, and be administered in accordance with the label instructions. There must be a diagnosis determined by a veterinary surgeon that supports the use of a bisphosphonate as an appropriate treatment, and such treatment must be administered by a veterinary surgeon.
• Nebulisers are not allowed on race day.
• No medication will be permitted on race day.
• Throat flushes, no matter how innocuous their ingredients, are not accepted.
• The application of ice or chilled water to, or the use of whirlpool boots or similar systems on musculoskeletal structures are only permitted in the trainers’ stables on the morning of the race day, but are not permitted once the horse arrives in the race day stalls on the racecourse prior to the horse running in a race.
For further information on prohibited substances, treatment and medication, please contact: